Chemical Name: (2R)-2-Deoxy-2-fluoro-2-methyl-D-erythropentonic acid gamma-lactone 3,5-dibenzoate
CAS.NO: 874638-80-9
Synonyms:
[(2R,3R,4R)-3-benzoyloxy-4-fluoro-4-methyl-5-oxooxolan-2-yl]methyl benzoate
[(2R,3R,4R)-3-(Benzoyloxy)-4-fluoro-4-methyl-5-oxotetrahydro-2-furanyl]methyl benzoate
((2R,3R,4R)-3-(benzoyloxy)-4-fluoro-4-methyl-5-oxotetrahydrofuran-2-yl)methyl benzoate
Molecular Formula: C20H17FO6
Molecular Weight: 372.34400
Physical and Chemical Properties:
Density: 1.3±0.1 g/cm3
Boiling point: 458.6±34.0 °C at 760 mmHg
Melting point: 133℃
Flash point: 222.9±20.6 °C
Refractive index: 1.577
Specification:
Appearance: White powder
Purity:≥98.0%
Loss on Drying:No more than 0.5%
Packing:
25kg cardboard drum or according to customer specified requirements
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Application:
(2R)-2-Deoxy-2-fluoro-2-methyl-D-erythropentonic Acid γ-Lactone 3,5-Dibenzoate is a reactant used in the synthesis of 1'-C-cyano-2'-fluoro-2'-C-methyl pyrimidine nucleosides as HCV polymerase inhibitors.intermediates of Sofosbuvir CAS:1190307-88-0.
| Items of Analysis | Standard of Analysis | Test Results | |
| Appearance | White to off-white solid or light brown solid | Off-white solid | |
| Identification (IR) | IR spectrum match with reference standard | Conforms | |
| Identification (HPLC) | The retention time of the main peak consistent with the reference | Conforms | |
| Purity (HPLC, %area) | ≥98 | 99.0 | |
| Assay (HPLC, %w/w) | 97.5～102.0 | 98.6 | |
|
Impurity (HPLC, %area) |
2-α Chlorinated impurity and 2-β Chlorinated impurity | ≤0.70 | 0.32 |
| 2-α Hydroxyl impurity and 2-β Hydroxyl impurity | ≤0.20 | Not detected | |
| Other single impurities | ≤0.30 | RRT=0.64 0.22 | |
| Report other impurities with RRT which assay is more than 0.05 | RRT=1.14 0.23 | ||
| Total impurity | ≤2.0 | 0.78 | |
|
L-Enantiomer (HPLC, %area) |
≤0.15 | Not detected | |
| Water (K.F., %w/w) | ≤0.10 | 0.04 | |
|
Loss on drying (105℃,1h,%w/w) |
≤0.50 | 0.01 | |
| Specific rotation | +130°～+140° | +135° | |
| Residue on Ignition (%w/w) | ≤0.50 | 0.03 | |
| Conclusion | Conforms to Factory Standard | ||
UNICHEMIST manufacture & supply (2R)-2-Deoxy-2-fluoro-2-methyl-D-erythropentonic acid gamma-lactone 3,5-dibenzoate CAS:874638-80-9,if you want to buy it,please drop your inquiry to [email protected] ,we will reply you asap.If you have any custom synthesis or contract manufacturing compounds, please also feel free to contact us.
Factory in Henan Province
The Henan factory is located in the south of Tengda Road and the west of Gongye 3rd Road, Huaiyang District, Zhoukou City, Henan Province. The first phase covers an area of about 200 acres with a total construction area of about 170,496 square meters. It is mainly engaged in the production and sales of pharmaceutical and biological products. More than 800 acres are planned for the second phase. The company has established a stable production service system that can meet the requirements of different quality assurance systems and process conditions, and can realize small-scale process transfer, pilot scale-up, and industrialization, as well as corresponding document registration and auditing.
Factory in Shanxi Province
At the end of 2017, We invested workshop in Xinjiang County Longzhou Chemical Co., Ltd., Xinjiang County Coal Mine Park, Yuncheng, Shanxi. The first phase of the reactors were 30* 2000L~5000L, The contract output value is 50 million annually, factory has passed the audit from public listed company domestic and abroad.
Factory in Shandong Province
The Shandong production plant is located in Liaocheng City, Shandong Province. It has a production workshop covering an area of 2600m², a supporting material warehouse of 800m², a QC laboratory of 150m², and a number of 500~5000L reactors. It has successfully carried out a number of scale-up production projects. The annual output of the body is more than 200 tons.
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